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pentobarbital will lower the level or result of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with sturdy CYP3A4 inducers is just not suggestedUsually do not use pentobarbital in individuals with hypersensitivity to barbiturates or any of the components in pentobarbital.DRUG ABUSE AND DEPEND